Functional interaction between Mus81-Mms4 and Rad52 in Saccharomyces cerevisiae
Nội dung chính của bài viết
Tóm tắt
Mus81-Mms4 is a well conserved DNA structure–specific endonuclease and efficiently cleaves different DNA structures that could arise during the repair of stalled/blocked replication forks and homologous recombination repair. Rad52 is an ezyme that stimulates main steps of DNA sequence-homology searching. In this study, we proved that Rad52 and Mus81-Mms4 possess a species-specific functional interaction, indicating that Rad52 and Mus81-Mms4 collaborate in processing of homologous recombination intermediates.
Từ khóa
functional interaction, homologous recombination, Mus81, Rad52.