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Date Published: 30/06/2025
Abstract Views: 216
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DOI: 10.54607/hcmue.js.22.6.4648(2025)
Issue
Vol. 22 No. 6 (2025)
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Articles
How to Cite
Nguyen, D. H., Truong, Q. H., & Nguyen, Q. T. (2025). XANTHINE OXIDASE INHIBITORY AND ANTICANCER ACTIVITIES OF Dischidia major (Vahl) Merr. EXTRACT FROM PHU QUOC. HCMUE Journal of Science, 22(6), 1047-1055. https://doi.org/10.54607/hcmue.js.22.6.4648(2025)

XANTHINE OXIDASE INHIBITORY AND ANTICANCER ACTIVITIES OF Dischidia major (Vahl) Merr. EXTRACT FROM PHU QUOC

Nguyen Duc Hien1, Truong Quoc Hung, Nguyen Quoc Trung1,
1 Trường Đại học Khoa học tự nhiên, ĐHQG-HCM

Main Article Content

Abstract

Dischidia major (Vahl) Merr., a native plant species with promising medicinal potential, has yet to be comprehensively studied in Vietnam. This study was conducted to evaluate the xanthine oxidase inhibitory activity, biocompatibility on HEK293 cells, and anticancer effects on HepG2 and MCF7 cell lines of methanol extract from Dischidia major. The extract was quantitatively analyzed for polyphenols, flavonoids, saponins, and alkaloids. The results revealed that the methanol extract contained polyphenols (191.18 ± 6.57 mg GAE/g), flavonoids (32.09 ± 1.11 mg QE/g), alkaloids (189.79 ± 8.13 mg AE/g), and saponins (215.33 ± 4.41 mg OAE/g). The extract demonstrated xanthine oxidase inhibitory activity with an IC50 value of 46.4 µg/mL, biocompatibility on HEK293 cells, and inhibited the proliferation of HepG2 and MCF7 cancer cell lines with IC50 values of 84.50 µg/mL and 73,74 µg/mL, respectively. This study highlights the potential of Dischidia major extract in the development of therapeutic agents for the treatment of gout and cancer.

Keywords

alkaloids, cancer, Dischidia major (Vahl) Merr., flavonoids, polyphenols, saponins, xanthine oxidase

Article Details

Author Biography

Nguyen Quoc Trung, Trường Đại học Khoa học tự nhiên, ĐHQG-HCM

 

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