Preparing and evaluating the antioxidant of an acid derivative from a monocarbonyl curcumin analog of cyclopentanone

Abstract

The monocarbonyl curcumin analog derivatives of cyclopentanone have been interested since these have various biological activities. Chalcone 2 was a product of the aldol condensation between vanillin and cyclopentanone in moderate yield. The Williamson ether synthesis was employed to form an ester 3 form the chalcone 2 in good yield. The hydrolysis reaction of compound 3 was carried out successfully forming compound 4. Structures of new compounds 3 and 4 were determined with IR, NMR and MS spectra. Compound 4 was not against DPPH free radical.