EXAMINATION OF PROTECTIVE ROLE OF LY SON GARLIC JUICE ON ARSENIC TOXICITY ON THE BLOOD CELLS COUNT, ERYTHROCYTE SHAPE AND HISTOPATHOLOGICAL PERSPECTIVES OF THE SPLEEN OF MALE ALBINO MOUSE
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Abstract
This study aimed to evaluate the protective role of Ly Son garlic juice on arsenic toxicity (450 μg/L) in male mice by the blood cell count, erythrocyte shape and spleen damages. Forty-eight male mice (six-week-old) were randomly classified into four groups: Group I (control), Group II (As); Group III (T250): As and 250 mg/kg/day garlic juice and Group IV (T500): As and 500 mg/kg/day garlic juice. The mice were forced to drink arsenic and garlic juice for 60 days. The blood cell counts, erythrocyte shapes were determined at 0, 30, 60 days. After 60 days, spleens were carefully collected and stained with hematoxylin and eosin to assess their histological damages. The results show the potential capacity of garlic juice in keeping the blood cell counts and erythrocyte shape in balance during the arsenic exposure. At the 30th day, the red blood cell counts decreased (T250 and T500) while the white blood cell and platelet counts were kept in balance in the T250 group. At the 60th day, the red blood cell counts were restored to the balanced state in the T250 and T500 group, while the other counts decreased. The histopathological analysis also shows that the structures of the spleen were badly injured by arsenic; the capacity of garlic juice in the protection of spleen induced from arsenic toxicity in male mice.
Keywords
arsenic toxicity, histopathological perspectives, Mice blood cells, Ly Son garlic
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References
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