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Date Published: 30/03/2021
Online Published: 30/03/2021
Abstract Views: 124
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DOI: https://doi.org/10.54607/hcmue.js.18.3.2937(2021)
Issue
Vol. 18 No. 3 (2021)
Section
Articles
How to Cite
Trương , T. T., Nguyễn , S. Đ. A., & Nguyễn , T. L. T. (2021). SYNTHESIS OF AMPHIPHILIC HAIRY ROD DIBLOCK POLY(GLUTAMIC ACID)-B-POLY(BENZYL GLUTAMATE-R-OCTADECYL GLUTAMATE). HCMUE Journal of Science, 18(3), 431. https://doi.org/10.54607/hcmue.js.18.3.2937(2021)

SYNTHESIS OF AMPHIPHILIC HAIRY ROD DIBLOCK POLY(GLUTAMIC ACID)-B-POLY(BENZYL GLUTAMATE-R-OCTADECYL GLUTAMATE)

Thu Thuỷ Trương 1, Song Đức Anh Nguyễn 2, Thị Lệ Thu Nguyễn 3,
1 Faculty of Materials Technology - Ho Chi Minh City University of Technology - Vietnam National University (VNU-HCM)
2 National key laboratory of Polymer and Composite materials – Ho Chi Minh City University of Technology – Vietnam National University (VNU-HCM)
3 - National key laboratory of Polymer and Composite materials – Ho Chi Minh City University of Technology – Vietnam National University (VNU-HCM) - Faculty of Materials Technology - Ho Chi Minh City University of Technology - Vietnam National University (VNU-HCM)

Main Article Content

Abstract

 

Diblock copolypeptide poly(glutamic acid) -b-poly (benzyl glutamate-r-octadecyl glutamate) has a great potential for biological stabilization and optical orientation. This study reports on the synthesis and characterization of an amphiphilic diblock copolypeptide of poly(glutamic acid) and poly(benzyl glutamate-r-octadecyl glutamate) possessing the a-helical secondary structure. To obtain this copolypeptide, a precursor copolymer with an acid-labile protecting group for the carboxylic acid was prepared through glutamate-N-carboxy anhydride polymerization, followed by removal of the protecting group using a straightforward and highly efficient process. The precursor and the synthesized diblock copolymer were characterized by using nuclear magnetic resonance spectroscopy (NMR) and attenuated total reflection-Fourier transform infrared (ATR FT-IR). The α-helix conformation of poly (glutamic acid) -b-poly (benzyl glutamate-r-octadecyl glutamate) was identified by the characteristic α-helix amide I and amide II bands at 1651 cm-1 and 1547 cm-1 respectively, the thermal properties of this diblock copolypeptide shown on a result of TGA for observing thermally stable up to 215 oC.

 

Keywords

Amphiphilic diblock copolypeptide, N-carboxyanhydride polymerization, poly(tert-butyl glutamate)

Article Details

References

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