NGHIÊN CỨU ĐIỀU CHẾ THUỐC PHÓNG XẠ 32P-CHROMIC PHOSPHATE TRÊN LÒ PHẢN ỨNG HẠT NHÂN ĐÀ LẠT ỨNG DỤNG TRONG ĐIỀU TRỊ UNG THƯ

Abstract

In this article, the radiopharmaceutical ³²P-Chromic phosphate was synthesized in Dalat Nuclear Reactor for studying and optimizing synthetic experimental parameters. Radiochemical purity was tested by paper chromatography with the Cyclone Plus Phosphor Scanner. Radionuclidic purity was tested on Aloka beta spectrometer. Sterility was performed by sterile testing. Bacterial endotoxins were experimented on Endosafe-PTS 100 (Portable Test System, PTS). The radiopharmaceutical ³²P-Chromic phosphate synthesized achieved an overall efficiency of 87,67%, radionuclidic purity of 99,90%, radiochemical purity  of 99,50%, bacterial endotoxins of 0,066 EU/ml/kg, and sterility. Thus, the radiopharmaceutical ³²P-Chromic phosphate meets the standards of American Pharmacopoeia 35 in cancer treatment.