SOME TERPENOID, FLAVONOID, AND MONOCYCLIC AROMATIC COMPOUNDS FROM LEAVES OF VITEX NEGUNDO
Main Article Content
Abstract
Seven compounds including abietatriene (1), oleanolic acid (2), quercetagetin 3,7-dimethyl ether (3), luteolin (4), p-hydroxybenzoic acid (5), p-methylbenzoic acid (6), and protocatechuic acid (7) were isolated from the n-hexane: ethyl acetate (1:1) extract of Vitex negundo leaves collected in Binh Thuan Province. Their chemical structures were elucidated by comparing their spectroscopic data with reported data in the literature. Six compounds (exception of 4) were known to be present in Vitex negundo.
Keywords
flavonoid, monocyclic aromatic compounds, terpenoid, Vitex negundo
Article Details
References
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Ulubelen, A., Kerr, K. M., & Mabry, T. J. (1980). New 6-hydroxyflavonoids and their methyl ethers and glycosides from Neurolaena oaxacana. Phytochemistry, 19(8), 1761-1766.
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Xin, H., Kong, Y., Wang, Y., Zhou, Y., Zhu, Y., Li, D., & Tan, W. (2013). Lignans extracted from Vitex negundo possess cytotoxic activity by G2/M phase cell cycle arrest and apoptosis induction. Phytomedicine, 20(7), 640-647.
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Arulvasu, C., Prabhu, D., Manikandan. R., Srinivasan, P., Dinesh, D., Babu, G., & Sellamuthu, S. (2010). Induction of apoptosis by the aqueous and ethanolic leaf extract of Vitex negundo L. in MCF-7 human breast cancer cells. Int J Drug Disco, 2(1), 1-7.
Díaz, F., Chávez, D., Lee, D., Mi, Q., Chai, H. B., Tan, G. T., Kardono, L. B. S., Riswan, S., Craig, R. F., Wild, R., Norman, R. F., Cordell, G. A., Pezzuto, J. M., & Kinghorn, A. D. (2003). Cytotoxic flavone analogues of vitexicarpin, a constituent of the leaves of Vitex negundo. J Nat Prod, 66(6), 865-867.
Gautam, L. M., Shrestha, S. L., Wagle, P., & Tamrakar, B. M. (2008). Chemical constituents from Vitex negundo (Linn.) of nepalese origin. Sci world, 6(6), 27-32.
Grayer, R. J., Eckert, M. R., Lever, A., Veitch, N. C., Kite, G. C., & Paton, A. J. (2010). Distribution of exudate flavonoids in the genus Plectranthus. Biochem Syst Ecol, 38(3), 335-341.
Guvenalp, Z., Ozbek, H., Kuruuzumuz, A., Kazaz, C., & Demirezer, L. O. (2009). Secondary metabolites from Nepeta heliotropifolia. Turk J Chem, 33, 667-675.
Kannikaparameswari, N., & Indhumathi, T. (2013). Haematological and cytotoxic effect of the ethanolic extract of Vitex negundo. Pharm Res, 2(1), 247-253.
Khokra, S. L., Prakash, O., Jain, S., Aneja, K. R., & Dhingra, Y. (2008). Essential oil composition and antibacterial studies of Vitex negundo Linn. extracts. Indian J Pharm Sci, 70(4), 522-526.
Lin, Z., Fang, Y., Huang, A., Chen, L., Guo, S., & Chen, J. (2014). Chemical constituents from Sedum aizoon and their hemostatic activity. Pharm Biol, 52(11), 1429-1434.
Malik, A., Khan, M. T. H., Khan, S. B., Ahmad, A.,& Choudhary, M. I. (2006). Tyrosinase inhibitory lignans from the methanol extract of the roots of Vitex negundo Linn. and their structure–activity relationship. Phytomedicine, 13(4), 255-260.
Okamura, N., Haraguchi, H., Hashimoto, K., & Yagi, A. (1994). Flavonoids in Rosmarinus officinalis leaves. Phytochemistry, 37(5), 1463-1466.
Rideout, J. A., Ragasa, C. Y., & Morales, E. (1999). Antimicrobial compounds from Vitex negundo. Philipp J Sci, 128, 22-29.
Shahnaz, S., Mohammed, A., & Showkat, R. M. (2017). Chemical constituents from the stem bark of Vitex negundo L. J Chem Res, 2(5), 29-37.
Sharma, R. L., Prabhakar, A., Dhar, K. L., & Sachar, A. (2009). A new iridoid glycoside from Vitex negundo Linn (Verbenacea). Nat Prod Res, 23(13), 1201-1209.
Tandon, V. R., Khajuria, V., Kapoor, B., Kour, D., & Gupta, S. (2008). Hepatoprotective activity of Vitex negundo leaf extract against anti-tubercular drugs induced hepatotoxicity. Fitoterapia, 79, 533-538.
Tsujimura, M., Goto, M., Tsuji, M., Yamaji, Y., Ashitani, T., Kimura, K., Ohira, T., & Kofujita, H. (2019). Isolation of diterpenoids from sugi wood-drying byproducts and their bioactivities. J Wood Sci, 65, 19-28.
Ulubelen, A., Kerr, K. M., & Mabry, T. J. (1980). New 6-hydroxyflavonoids and their methyl ethers and glycosides from Neurolaena oaxacana. Phytochemistry, 19(8), 1761-1766.
Wu, Y. N., Fu, M. C., Shang, R., & Fu, Y. (2020). Nickel-catalyzed carboxylation of aryl iodides with lithium formate through catalytic CO recycling. Chem Commun (Camb), 56(29),
4067-4069.
Xin, H., Kong, Y., Wang, Y., Zhou, Y., Zhu, Y., Li, D., & Tan, W. (2013). Lignans extracted from Vitex negundo possess cytotoxic activity by G2/M phase cell cycle arrest and apoptosis induction. Phytomedicine, 20(7), 640-647.
Zheng, C. J., Lan, X. P., Cheng, R. B., Huang, B. K., Han, T., Zhang, Q. Y., Zhang, H., & Rahman, K. (2011). Furanofuran lignans from Vitex negundo seeds. Phytochem Lett, 4(3), 298-300.
Zheng, C. J., Pu, J., Zhang, H., Han, T., Rahman, K., & Qin, L. P. (2012). Sesquiterpenoids and norterpenoids from Vitex negundo. Fitoterapia, 83(1), 49-54.