Article Sidebar

PDF
Date Published: 30/11/2022
Online Published: 30/11/2022
Abstract Views: 544
Views PDF: 369
DOI: https://doi.org/10.54607/hcmue.js.19.11.3521(2022)
Issue
Vol. 19 No. 11 (2022)
Section
Articles
How to Cite
Doan , C. C., La , T. H. L., Lê , T. L., Hoàng , N. S., Bùi , Đ. T., Vũ , Q. Đ., & Nguyễn , T. T. H. (2022). PREPARATION OF FILM-COATED TABLETS CONTAINING CURCUMA SINGULARIS RHIZOME EXTRACT. HCMUE Journal of Science, 19(11), 1808. https://doi.org/10.54607/hcmue.js.19.11.3521(2022)

PREPARATION OF FILM-COATED TABLETS CONTAINING CURCUMA SINGULARIS RHIZOME EXTRACT

Chinh Chung Doan , Thị Hồng Lan La , Thành Long Lê , Nghĩa Sơn Hoàng , Đình Thạch Bùi , Quang Đạo Vũ , Thị Thương Huyền Nguyễn

Main Article Content

Abstract

Curcuma singularis (CS) Gagnep is commonly known in Vietnam as “Sam da” or “cay khoe,” which belongs to the Curcuma genus, Zingiberaceae family. CS rhizomes were extensively used as a folk medicine for boosting health. However, CS rhizome extract has a bitter taste and is unpleasant for consumption as a medicinal agent. Therefore, this study aimed to formulate and prepare film-coated tablets containing CS rhizome dried extract. In this study, CS rhizome extract meets medicinal quality requirements of in-house standards based on the latest version of Vietnam Pharmacopoeia V. Corn starch was used to produce a dried extract. The core tablets of CS rhizome were prepared by direct compression technique with the combination of various excipients in the formula and then coated with HPMC-E6 and PEG-6000 to obtain film-coated tablets. Our results showed that the formulation and preparation process for film-coated tablets containing CS rhizome extract was successfully established. The product met the quality standards in accordance with the proposed specifications.

 

Keywords

Curcuma singularis, film-coated tablets, germacrone

Article Details

References

Doan, C. C., Le, T. L., Ho, N. Q. C., La, T. H. L., Nguyen, V. C., Le, V. D., Nguyen, T. P. T, & Hoang, N. S. (2021). Bioactive chemical constituents, in vitro anti-proliferative activity and in vivo toxicity of the extract of Curcuma singularis Gagnep rhizomes. Journal of Ethnopharmacology, 5, 114803.
European Medicines Agency. (2005). ICH Topic Q2 (R1) Validation of Analytical Procedures. Text and Methodology, International Conference on Harmonization.
Lim, M. S., Choung, S. Y., & Jeong, K. W. (2016). Germacrone inhibits estrogen receptor α-mediated transcription in MCF-7 breast cancer cells. Phytotherapy Research, 30(12), 2036-2043.
Liu, B., Gao, Y. Q., Wang, X. M., Wang, Y. C., & Fu, L. Q. (2013). Germacrone inhibits the proliferation of glioma cells by promoting apoptosis and inducing cell cycle arrest. Molecular Medicine Reports, 10(2), 1046-1050
Liu, Y., Wang, W., Fang, B., Ma, F., Zheng, Q., Deng, P., Zhao, S., Chen, M., Yang, G., & He, G. (2013). Anti-tumor effect of germacronee on human hepatoma cell lines through inducing G2/M cell cycle arrest and promoting apoptosis. European Journal of Pharmacology,
698(1-3), 95-102.
Liu, Y., Wang, W., Fang, B., Ma, F., Zheng, Q., Deng, P., Zhao, S., Chen, M., Yang, G., & He, G. (2013). Anti-tumor effect of germacrone on human hepatoma cell lines through inducing G2/M cell cycle arrest and promoting apoptosis. European Journal of Pharmacology,
2698(1-3), 95-102.
Nguyen, M. C., Vu, T. H., Pham, N. K., Doan, T. V., To, D. C., Tran, T. H., … Nguyen, Q. B. (2017). Chemical compositions and antimicrobial activity of essential oil from the rhizomes of Curcuma singularis growing in Vietnam. American Journal of Essential Oils and Natural Products, 5, 20-25.
Nguyen, V. C., La, T. H. L., Le, T. L., Hoang, N. S., & Doan C. C. (2021). Xay dung quy trinh dinh luong germacrone trong cao chiet tu re cu csy Sam da (Curcuma singularis) bang phuong phap sac ki long hieu nang cao. [High performance liquid chromatography determination of gemacrone in the root extract of Curcuma singularis]. Journal of Medicine and Pharmacy, 20, 32-36.
Nguyen, V. C., Tran T. K. V., Le, T. L., Hoang, N. S., & Doan, C. C. (2022). Xay dung quy trinh dinh luong germacron trong vien nen bao phim chua cao chiet tu than re cay Sam đa
(Curcuma singularis) bằng phuong phap sac ki long hieu nang cao. [Determination of germacrone in film-coated tablet containing Curcuma singularis extract by high performance liquid chromatography-HPLC]. Journal of Medicine and Pharmacy, 42, 34-40.
Vietnamese Pharmacopoeia V. (2018). Monographs on medicinal plant extracts, oils and essential oils. Retrieved from https://vnras.com/wp-content/uploads/2018/04/VNRAS-22-DDVN-5-TAP-2-CHUYEN-LUAN-CAO-DUOC-LIEU-DAU-TINH-DAU.pdf
Vietnamese Pharmacopoeia V. (2018). Appendix 3, 4, 5 ,6, 7 and 8. (https://vnras.com/wp-content/uploads/2018/04/VNRAS-27-DDVN-5-TAP-2-PHU-LUC-PHU-LUC-345678.pdf
Vietnamese Pharmacopoeia V. (2018). Appendix 9, 10 and 11. Retrieved from https://vnras.com/wp-content/uploads/2018/04/VNRAS-28-DDVN-5-TAP-2-PHU-LUC-PHU-LUC-91011.pdf
Zhong, Z., Chen, X., Tan, W., Xu, Z., Wu, T., Cui, L., & Wang, Y. (2011). Germacrone inhibits the proliferation of breast cancer cell lines by inducing cell cycle arrest and promoting apoptosis. European Journal of Pharmacology, 667(1-3), 50-55.