SOME FLAVONOIDS FROM LEAVES OF ARTOCARPUS INTEGER GROWING IN BINH PHUOC PROVINCE

Minh Khải Đặng , Thu Hoàng Mai Nguyễn , Hữu Phước Trần , Nam Phương Nguyễn , Đức Dũng Phạm , Thúc Huy Dương

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Abstract

 

Artocarpus integer has been used as traditional medicine in Asian countries. This plant is common in Southern provinces of Vietnam, such as Binh Phuoc, Gia Lai, and Dong Nai. Investigation of the phytochemical of fruits of Artocarpus integer showed that flavonoid derivatives exhibited anti-inflammatory, antioxidant, antibacterial properties, and enzyme α-glucosidase inhibitions. This study isolated some compounds from ethyl acetate extract of leaves of Artocarpus integer. Four compounds including catechin (1), epi-catechin (2), (2S)-8-(3''-methylbut-2''-enyl)-7,3',4'-trihydroxyflavanone (3), and (2S)-liquiritigenin (4) were isolated from the ethyl acetate extract of Artocarpus integer leaves collected in Binh Phuoc Province. Their chemical structures were elucidated by comparing their spectroscopic data with reported data in the literature.

 

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References

Davis, A. L., Cai, Ya., Davies, A. P., & Lewis J. R. (1996). 1H and 13C NMR Assignments of Some Green Tea Polyphenols.
Do, T. L. (2004). Nhung cay thuoc va vi thuoc Viet Nam [Vietnam medicinal plants and herbs]. Medical Publishing House.
Duong, T. H., Nguyen, H. T., Nguyen, C. H., Tran, N. M. A., Danova, A., Tran, T. M. D., Vu-Huynh, K. L., Musa, V., Jutakanoke, R., Nguyen, N. H., & Sichaem, J. (2021). Identification of highly potent α-glucosidase inhibitors from Artocarpus integer and molecular docking studies. Chemistry and Biodiversity, 18(12). doi: 10.1002/cbdv.202100499
Jagtap, U. B., & Bapat, V. A. (2010). Artocarpus: A review of its traditional uses, phytochemistry and pharmacology. In Journal of Ethnopharmacology.
J. Ethnopharmacol, 129(2), 142–166. doi: 10.1016/j.jep.2010.03.031
Lee, E. J., Shaikh, S., Ahmad, K., Ahmad, S. S., Lim, J. H., … Choi, I. (2021). Isolation and characterization of compounds from Glycyrrhiza uralensis as therapeutic agents for the muscle disorders. International Journal of Molecular Sciences, 22(2), 1-20. doi: 10.3390/ijms22020876
Mungmee, C., Sitthigool, S., Buakeaw, A., & Suttisri, R. (2013). A new biphenyl and other constituents from the wood of Garcinia schomburgkiana. Natural Product Research, 27(21), 1949–1955. doi: 10.1080/14786419.2013.796469
Panthong, K., Tohdee, K., Hutadilok-Towatana, N., Voravuthikunchai, S. P., & Chusri, S. (2013). Prenylated flavone from roots of a hybrid between Artocarpus heterophyllus and Artocarpus integer and its biological activities. Journal of the Brazilian Chemical Society, 24(10),
1656-1661. doi: 10.5935/0103-5053.20130212
Uriburu, M. L., Gil, R. R., Sosa, V. E., & de la Fuente, J. R. (2007). Prenylflavonoids from Flourensia fiebrigii. Phytochemistry, 68(9), 1295-1299. doi: 10.1016/j.phytochem.2007.01.004