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Date Published: 23/01/2024
Online Published: 31/01/2024
Abstract Views: 221
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DOI: https://doi.org/10.54607/hcmue.js.21.1.3972(2024)
Issue
Vol. 21 No. 1 (2024)
Section
Articles
How to Cite
Nguyễn , Q. T., & Tiêu , D. L. (2024). A STUDY ON THE SCAVENGING DPPH RADICAL INHIBITOR, Α-GLUCOSIDASE ENZYME, AND ANTIBACTERIAL ACTIVITY OF GAC (MOMORDICA COCHINCHINENSIS) SEED EXTRACT. HCMUE Journal of Science, 21(1), 150. https://doi.org/10.54607/hcmue.js.21.1.3972(2024)

A STUDY ON THE SCAVENGING DPPH RADICAL INHIBITOR, Α-GLUCOSIDASE ENZYME, AND ANTIBACTERIAL ACTIVITY OF GAC (MOMORDICA COCHINCHINENSIS) SEED EXTRACT

Quốc Trung Nguyễn , Diệu Linh Tiêu

Main Article Content

Abstract

Momordica cochinchinensis is a common plant species with many therapeutic effects in traditional medicine. This study was conducted to investigate the inhibitory activities of DPPH radicals, α-glucosidase enzymes, and antibacterial of ethanol extract of gac seeds collected in Kien Giang Province. The results showed that ethanol extract of gac seeds exhibited DPPH and α-glucosidase inhibitory activities through IC50 values of 61.82 µg/mL and 65.66 µg/mL, respectively. In addition, the ethanol extract of gac seeds had antibacterial activity against all four tested microorganisms: Escherichia coli, Listeria innocua, Vibrio parahaemolyticus, and Samonella typhimurium. The results contribute to enriching information about the biological activity of this medicinal source in Vietnam.

 

Keywords

α-glucosidase, DPPH, gac seed, antibacterial, Momordica cochinchinensis

Article Details

Author Biographies

Quốc Trung Nguyễn,

 

Diệu Linh Tiêu,

 

References

Abdulqader, A., Ali, F., Ismail, A., & Esa, N. M. (2019). Antioxidant compounds and capacities of Gac (Momordica cochinchinensis Spreng) fruits. Asian Pacific Journal of Tropical Biomedicine, 9(4), 158-167. http://dx.doi.org/10.4103/2221-1691.256729
Antonio, M. A., & Vivit, M. B. (2017). Phytoconstituents and in vitro anti-oxidant activity of selected indigenous vegetables in the Ilocos. MMSU Science and Technology Journal, 7(2), 16-27.
Biswas, B., Rogers, K., McLaughlin, F., Daniels, D., & Yadav, A. (2013). Antimicrobial activities of leaf extracts of guava (Psidium guajava L.) on two gram-negative and gram-positive bacteria. International journal of microbiology, 2013, Article 746165. https://doi.org/10.1155/2013/746165
Biswas, S. K., Chowdhury, A., Raihan, S. Z., Muhit, M. A., Akbar, M. A., & Mowla, R. (2012). Phytochemical investigation with assessment of cytotoxicity and antibacterial activities of chloroform extract of the leaves of Kalanchoe plnnata. American Journal of Plant Physiology, 7(1), 41-46. https://doi.org/10.3923/ajpp.2012.47.52
Canillac, N., & Mourey, A. (2001). Antibacterial activity of the essential oil of Picea excelsa on Listeria, Staphylococcus aureus and coliform bacteria. Food Microbiology, 18(3), 261-268. https://doi.org/10.1006/fmic.2000.0397
Do, T. V. T., Fan, L., Suhartini, W., & Girmatsion, M. (2019). Gac (Momordica cochinchinensis Spreng) fruit: A functional food and medicinal resource. Journal of functional foods, 62, Article 103512. https://doi.org/10.1016/j.jff.2019.103512
Kubola, J., & Siriamornpun, S. (2011). Phytochemicals and antioxidant activity of different fruit fractions (peel, pulp, aril and seed) of Thai gac (Momordica cochinchinensis Spreng). Food chemistry, 127(3), 1138-1145. https://doi.org/10.1016/j.foodchem.2011.01.115
Le, A. V., Parks, S. E., Nguyen, M. H., & Roach, P. D. (2018). Optimisation of the microwave-assisted ethanol extraction of saponins from Gac (Momordica cochinchinensis Spreng.) seeds. Medicines, 5(3), 70, Article 5030070. https://doi.org/10.3390/medicines5030070
Liao, Y., Li, Z., Zhou, Q., Sheng, M., Qu, Q., Shi, Y., Yang, J., Lv, L., Dai, X., Shi, X. (2021). Saponin surfactants used in drug delivery systems: A new application for natural medicine components. International journal of pharmaceutics, 603, Article 120709. https://doi.org/10.1016/j.ijpharm.2021.120709
Mehany, T., Khalifa, I., Barakat, H., Althwab, S. A., Alharbi, Y. M., & El-Sohaimy, S. (2021). Polyphenols as promising biologically active substances for preventing SARS-CoV-2: A review with research evidence and underlying mechanisms. Food Bioscience, 40, Article 100891. https://doi.org/10.1016/j.fbio.2021.100891
Moradabadi, L., Kouhsari, S. M., & Sani, M. F. (2013). Hypoglycemic effects of three medicinal plants in experimental diabetes: Inhibition of rat intestinal α-glucosidase and enhanced pancreatic Insulin and cardiac Glut-4 mRNAs expression. Iranian journal of pharmaceutical research: IJPR, 12(3), 387-397, Article 24250646.
Nguyen, Q. T., Nguyen, V. T., Nguyen, D. T., Pham, N. T., Nguyen, T. K., Nhi, T. T. Y., Tran, N. Q., Le Thi, P. (2023). Injectable hydrogel combining alginate and Rhodomyrtus tomentosa medicine with antibacterial, anti-inflammatory and cellular proliferation properties as potential wound dressing material. Materials Today Communications, 35, Article 106243. https://doi.org/10.1016/j.mtcomm.2023.106243
Sharma, O. P., & Bhat, T. K. (2009). DPPH antioxidant assay revisited. Food chemistry, 113(4), 1202-1205. https://doi.org/10.1016/j.foodchem.2008.08.008
Sheliya, M., Begum, R., Pillai, K., Aeri, V., Mir, S., Ali, A., & Sharma, M. (2016). In vitro a-glucosidase and a-amylase inhibition by aqueous, hydroalcoholic, and alcoholic extract of Euphorbia hirta L. Drug Development and Therapeutics, 7(1), 26-30. http://doi.org/10.4103/2394-6555.180156
Tang, G. Y., Zhao, C. N., Liu, Q., Feng, X. L., Xu, X. Y., Cao, S. Y., Meng, X., Li, S., Gan, R. Y., & Li, H. B. (2018). Potential of grape wastes as a natural source of bioactive compounds. Molecules, 23(10), Article 23102598. https://doi.org/10.3390/molecules23102598
Yu, J. S., Roh, H. S., Lee, S., Jung, K., Baek, K. H., & Kim, K. H. (2017). Antiproliferative effect of Momordica cochinchinensis seeds on human lung cancer cells and isolation of the major constituents. Revista Brasileira de Farmacognosia, 27, 329-333. https://doi.org/10.1016/j.bjp.2017.02.002