TERPENOID COMPOUNDS FROM THE EXTRACTED ETHYL ACETATE OF THE BARK STEM OF PHYLLANTHUS ACIDUS Bui Xuan Hao*, Huynh Kim Dung

Xuân Hào Bùi 1, , Kim Dung Huỳnh
1 ĐHSP TP.HCM

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Abstract

Thin layer chromatography and column chromatography were performed from the ethyl acetate extraction of the bark stem of Phyllanthus acidus, and six terpenoids were isolated, including four diterpenes and two triterpenes. Their names were phyllanthol (1), 19-acetoxy-16a, 17-dihydroxy-ent-kaurane (2), 16a, 17-dihydroxy-ent-kaurane (3), 16a,17-acetonide-3α-hydroxykauran (4), maslinic acid (5) and phyllane A (6). The structures of these compounds were elucidated by nuclear magnetic resonance spectroscopy. This is the first time that compounds 2, 3, 4, and 5 were found in the genus of Phyllanthus.

 

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References

Do, H. B. (2006). Vietnamese Medicinal Plants and Animals. Science and Technology Publisher. Hanoi.
Duong, T. H., Bui, X. H., Le Pogam, P., Nguyen, H. H., Tran, T. T., Chavasiri, W., & Boustie, J. (2017). Two novel diterpenes from the roots of Phyllanthus acidus (L.) Skeel. Tetrahedron, 73(38), 5634-5638.
Ikuta, A., Kamiya, K., Satake, T., & Saiki, Y. (1995). Triterpenoids from callus tissue cultures of Paeonia species. Phytochemistry, 38(5), 1203-1207.
Ndlebe, V. J., Crouch, N. R., & Mulholland, D. A., (2007). Triterpenoids from the African tree Phyllanthus polyanthus. Phytochem. Lett., 1, 11-17.
Piacente, S., Aquino, R., Tommasi, N. D., Pizza, C., & Ugaz, O. L. D., (1994). Constituents of Werneria ciliolata and their in vitro anti-HIV activity. Phytochemistry, 36(4), 991-996. https://doi.org/10.1016/s0031-9422(00)90477-1
Quach, T. T. V., Le, T. V., Tran, T. H. H., Phan, T. T. H., Nguyen, V. T., Nguyen, X. C., Nguyen, H. N., & Chau, V. M., (2019). Triterpenoid derivatives from Barringtonia racemose. Vietnam J. Chem., 57(1), 96-100. http://dx.doi.org/10.1002/vjch.201900006
Rumbero, A., Arriaga-Giner, F. J., & Wollenweber, E., (2000). New Constituents of the Leaf and Stem Exudate of Ozothamnus hookeri (Asteraceae). Z Naturforsch C J Biosci, 55(5-6), 318-322.
Turak, A., Maimaiti, Z., & Aisa, H. A., (2018). A new kaurane diterpene from the seeds of Vernonia anthelmintica. Chemistry of Natural Compounds, 54(3), 475-477. https://ui.adsabs.harvard.edu/link_gateway/2018CNatC..54..475T/doi:10.1007/s10600-018-2382-3
Woo, K. W., Han, J. Y., Choi, S. U., Kim, K. H., & Lee, K. R., (2014). Triterpenes from Perilla frutescens var. acuta and their cytotoxic activity. Nat. Prod. Sci., 20(2), 71-75.
Yang, Y. L., Chang, F. R., Wu, C. C., Wang, W. Y., & Wu, Y. C., (2002). New ent-Kaurane Diterpenoids with Anti-Platelet Aggregation Activity from Annona squamosa. J. Nat. Prod., 65, 1462-1467.