A SURVEY OF ACUTE TOXIC EFFECTS OF CADMIUM ON THE BRAIN OF ALBINO MICE
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Abstract
The objective of this study was to determine the LD50 of Cadmium in mice and assess the effects of acute Cd toxicity on their brains. Male mice were administered a single dose of Cd from CdCl2.2.5 H2O, starting at 330 mg/kg b.w, until a lethal dose for 50% of the tested mice was determined within 24-48 hours. The results revealed that the LD50 of Cd is 70 mg/kg b.w. Exposure to Cd doses ranging from 330 to 70 mg/kg b.w from CdCl2.2H2O resulted in significant alterations in behavior and histological structure of the mouse brain, including blood vessel enlargement, nerve cell degeneration, and necrosis. The severity of damage decreased as the Cd dosage was reduced from 330 mg/kg b.w to 70 mg/kg b.w. Further investigation into the effects of Cd on body weight, hematological parameters, and internal organs of mice is warranted to gain a comprehensive understanding of its physiological impact on albino mice.
Keywords
albino mice, cadmium, histopathological, LD50, neurotoxicity
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References
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