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Date Published: 30/10/2025
Abstract Views: 262
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DOI: 10.54607/hcmue.js.22.10.4684(2025)
Issue
Tập 22, Số 10(2025)
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Articles
How to Cite
Tran, C. T., Hoang, N. S., Le, P. C., Nguyen, T. T. H., Bui, Q. T., Nguyen, D. H., & Nguyen, T. T. H. (2025). EFFECTS OF BONE IMPLANT MATERIALS BCP (Basic Calcium Phosphate) AND BCP - NPS (Basic calcium phosphate – Nano porous silica) ON THE BLOOD CELLS AND INTERNAL ORGANS OF ALBINO MICE (Mus musculus var. Albino). Ho Chi Minh City University of Education Journal of Science, 22(10), 1900-1911. https://doi.org/10.54607/hcmue.js.22.10.4684(2025)

EFFECTS OF BONE IMPLANT MATERIALS BCP (Basic Calcium Phosphate) AND BCP - NPS (Basic calcium phosphate – Nano porous silica) ON THE BLOOD CELLS AND INTERNAL ORGANS OF ALBINO MICE (Mus musculus var. Albino)

Tran Cam Tu1, Hoang Nghia Son1, Le Phuc Chien1, Nguyen Thi Thanh Hang2, Bui Quoc Thang3, Nguyen Dai Hai4, Nguyen Thi Thuong Huyen5,
1 Institute of Tropical Biology, Vietnam Academy of Science and Technology, Vietnam
2 University of Science, Vietnam National University Ho Chi Minh City, Vietnam
3 Cho Ray Hospital, Vietnam
4 Institute of Chemical Technology, Vietnam Academy of Science and Technology, Vietnam
5 Ho Chi Minh City University of Education, Vietnam

Main Article Content

Abstract

This study examined the effects of bone implant materials BCP (Basic Calcium Phosphate) and BCP-NPS (Basic Calcium Phosphate – Nano Porous Silica) on hematological indices in an in vivo model of albino mice, aiming to estimate the effects of the materials on blood cell counts and internal organs. The experiment was conducted on 35 female albino mice, six weeks of age, using a bone injury model. The animals were assigned to five treatments: Control (DC), negative control (KC), research material BCP-NC, research material BCP-NPS, and positive control (BCP-TM). The results showed that both BCP and BCP-NPS implant materials affected fluctuations in blood cell counts in albino mice, particularly leukocytes and platelets at week 2. However, there were almost no differences after four weeks of experimentation, and all observed changes were not statistically significant (p > 0.05). Moreover, the materials did not induce severe effects on the liver, kidneys, and spleen of the mice. This confirms the potential application of BCP and BCP-NPS materials in bone grafting treatments, demonstrating their positive effects.

 

Keywords

BCP, Bone implant material, Histopathology, Mice blood cell, Mus musculus var. albino

Article Details

Author Biography

Tran Cam Tu, Institute of Tropical Biology, Vietnam Academy of Science and Technology, Vietnam

Phòng công nghệ sinh học động vật

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