ESTABLISHMENT OF BASIC QUALITY STANDARDS FOR EXTRACTS FROM Curcuma aromatica Salisb. RHIZOMES
Main Article Content
Abstract
Curcuma aromatica Salisb, commonly known as white turmeric or aromatic turmeric, belongs to the Zingiberaceae family and the Curcuma genus. This plant has been traditionally used to treat various ailments, including microbial infections, skin eruptions, coronary heart disease, and other diseases, due to its antioxidant, antibacterial, anti-angiogenic, anti-hepatotoxic, anti-inflammatory, and anti-tumor properties. The purpose of this study is to analyze the ethanol extract of C. aromatic rhizomes by evaluating several parameters, including sensory properties, pH, moisture content, total ash content, heavy metal content, microbiological limits, and the presence and concentrations of biological markers. The results of the study on the ethanol extract of C. aromatic rhizome are as follows: pH ranges from 6.2 to 6.7, moisture content is between 9.48% and 10.12%, total ash content varies from 9.88% to 10.67%. Notably, no heavy metals were detected, and the levels of bacterial contamination are within acceptable limits for medicinal herbs. Additionally, the content of germacrone and curdione in the extract is approximately 1.09% to 1.23% and 0.61% to 0.68%, respectively. This research establishes a basic standard for the ethanol extract of C. aromatic rhizomes, incorporating eight quality parameters, with six indicators meeting the quality standards set forth by the Vietnamese Pharmacopoeia V. The results contribute to improved quality control and enhanced effectiveness in the use of medicinal herbs, specifically white turmeric.
Keywords
Basic standards, Curcuma aromatica Salisb., extract, HPLC, Vietnamese Pharmacopoeia V.
Article Details
References
Do, D. M., Vo, T. H., Nguyen, D. H., Le, K. M., Huynh, T. H., Le, T. D. Q., & Huynh, T. T. (2019). Identification of Curcuma aromatica growing in Vietnam and its potential anticancer components. MedPharmRes, 3(3), 12–18. https://doi.org/10.32895/UMP.MPR.3.3.3
Dosoky, N. S., & Setzer, W. N. (2018). Chemical composition and biological activities of essential oils of Curcuma species. Nutrients, 10(9), 1196. https://doi.org/10.3390/nu10091196
Duong, T. N., Nguyen, T. N. V., Dang, D. K., Nguyen, N. N. T., & Nguyen, V. C. (2024). Nghiên cứu xây dựng tiêu chuẩn cơ sở của lá cây mắm lưỡi đồng (Avicennia officinalis L.) [Development of standard base of Avicennia officinalis L.]. Vietnam Medical Journal, 537(1), 369–374.
Fei, C., Ji, D., Tong, H., Li, Y., Su, L., Qin, Y., Bian, Z., Zhang, W., Mao, C., Li, L., & Lu, T. (2022). Therapeutic mechanism of Curcuma aromatica Salisb. rhizome against coronary heart disease based on integrated network pharmacology, pharmacological evaluation and lipidomics. Frontiers in Pharmacology, 13, 950749. https://doi.org/10.3389/fphar.2022.950749
Gu, J., Sun, R., Wang, Q., Liu, F., Tang, D., & Chang, X. (2021). Standardized Astragalus mongholicus Bunge-Curcuma aromatica Salisb. extract efficiently suppresses colon cancer progression through gut microbiota modification in CT26-bearing mice. Frontiers in Pharmacology, 12, 714322. https://doi.org/10.3389/fphar.2021.714322
Hu, B., Shen, K. P., An, H. M., Wu, Y., & Du, Q. (2011). Aqueous extract of Curcuma aromatica induces apoptosis and G2/M arrest in human colon carcinoma LS-174-T cells independent of p53. Cancer Biotherapy and Radiopharmaceuticals, 26(1), 97–104. https://doi.org/10.1089/cbr.2010.0853
ICH Harmonised Tripartite Guideline. (2015). Validation of analytical procedures: Text and methodology Q2(R1). International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use.
Kumar, A., Chomwal, R., Kumar, P., & Renu, S. (2009). Antiinflammatory and wound healing activity of Curcuma aromatica Salisb. extract and its formulation. Journal of Chemical and Pharmaceutical Research, 1(1), 304–310.
Le, T. N. A., Nguyen, D. H., & Vo, T. H. (2018). Xây dựng và thẩm định quy trình định lượng đồng thời curdion và germacron trong cao ngải trắng [Development and validation of an HPLC method for simultaneous determination of curdione and germacrone in the extracts from Curcuma aromatica Salisb.]. Pharmaceutical Journal, 58(8).
Liu, M., Wu, Y., Huang, S., Liu, H., & Feng, J. (2018). Spectrum-effect relationship between HPLC fingerprints and hypolipidemic effect of Curcuma aromatica. Biomedical Chromatography, 32(7), e4220. https://doi.org/10.1002/bmc.4220
Ma, J. W., Tsao, T. C. Y., His, Y. T., Lin, Y. C., Chen, Y., Chen, Y., Ho, C. T., Kao, J. Y., & Way, T. D. (2016). Essential oil of Curcuma aromatica induces apoptosis in human non-small-cell lung carcinoma cells. Journal of Functional Foods, 22, 101–112. https://doi.org/10.1016/j.jff.2016.01.019
Marina, G. D., Kekuda Prashith, T. R., & Sudarshan, S. J. (2008). Antitussive activity of ethanolic extract of Curcuma aromatica rhizomes on sulfur dioxide induced cough in mice. Ancient Science of Life, 27(3), 36–40.
Nguyen, V. C., Le, T. L., Hoang, N. S., Do, D. G., Do, D. T., Nguyen, T. T. H., & Doan, C. C. (2022). Establishment of a high-performance liquid chromatography method for quantification of isorhamnetin in extract of Anoectochilus roxburghii. Ho Chi Minh City University of Education Journal of Science, 19(9), 1453–1460. https://doi.org/10.54607/hcmue.js.19.9.3516(2022
Pintatum, A., Maneerat, W., Logie, E., Tuenter, E., Sakavitsi, M. E., Pieters, L., Berghe, W. V., Sripisut, T., Deachathai, S., & Laphookhieo, S. (2020). In vitro anti-inflammatory, anti-oxidant, and cytotoxic activities of four Curcuma species and the isolation of compounds from Curcuma aromatica rhizome. Biomolecules, 10(5), 799. https://doi.org/10.3390/biom10050799
Vo, T. H., Lê, N. H. N., Huynh, T. T., Do, D. M., Le, K. M., & Nguyen, D. H. (2019). Xây dựng quy trình định lượng đồng thời curdion và germacron trong thân rễ ngải trắng [Simultaneous determination of curdione and germacrone from rhizoma Curcumae aromaticae by high performance liquid chromatography HPLC]. Ho Chi Minh City Journal of Medicine, 23(2), 256.
Vo, V. C. (2018). Từ điển cây thuốc Việt Nam - Tập 1 [Dictionary of Vietnamese medicinal plants - Volume 1]. Medical Publishing House.
Xiang, H., Zhang, L., Yang, Z., Chen, F., Zheng, X., & Liu, X. (2017). Chemical compositions, antioxidative, antimicrobial, anti-inflammatory and antitumor activities of Curcuma aromatica Salisb. essential oils. Industrial Crops and Products, 108, 6–16. https://doi.org/10.1016/j.indcrop.2017.05.058